Title : Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists.

Pub. Date : 2010 Mar 1

PMID : 20144866






1 Functional Relationships(s)
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1 Thus, replacement of the dimethoxyphenyl by a substituted pyrazole and additional optimization of the substitution pattern of the phenethyl motif allowed the identification of potent antagonists with low nanomolar affinity for hOX(1)R and hOX(2)R. pyrazole hypocretin receptor 1 Homo sapiens