Title : Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients.

Pub. Date : 2010 May

PMID : 20143052






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 PURPOSE: The impact of the UGT1A4, CYP1A2, and MDR1 genetic variants on olanzapine plasma levels, in relation to those of other individual factors, such as gender, smoking status, body weight, and age, was investigated in patients with schizophrenia. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
3 RESULTS: In addition to , the results indicate that inter-patient differences in olanzapine exposure were explained by the known factor of time of sampling from last dose intake and by the following individual factors in order of relative impact: (1) male gender, (2) carrier of the UGT1A4 142T>G single nucleotide polymorphism (SNP), and (3) smoking. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
4 CONCLUSIONS: At 12 h after dose intake, the regression model predicted a 5.1-fold higher olanzapine plasma level in a non-smoking female patient who did not carry the UGT1A4 142T>G SNP compared to a smoking man treated with the same dose but heterozygous for UGT1A4 142T>G SNP. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens