Title : Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine.

Pub. Date : 2010 May

PMID : 20133892






1 Functional Relationships(s)
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1 The apparent K(m) (S(50)) values for the formation of quaternary N-glucuronides of amitriptyline, imipramine, clomipramine, and trimipramine were 2.60, 16.8, 14.4, and 11.2 microM in UGT2B10 and 448, 262, 112, and 258 microM in UGT1A4, respectively. n-glucuronides UDP glucuronosyltransferase family 1 member A4 Homo sapiens