Title : Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation.

Pub. Date : 2010 Nov

PMID : 20133359






1 Functional Relationships(s)
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1 Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice. ursolic acid interleukin 1 beta Mus musculus