Pub. Date : 2010 Mar 5
PMID : 20132794
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells. | Iodides | solute carrier family 5 member 5 | Rattus norvegicus |
| 2 | The functional effect of iodide occurs at multiple steps, which include inhibition of sodium/iodide symporter (NIS) expression, transient block of organification, and inhibition of hormonal release. | Iodides | solute carrier family 5 member 5 | Rattus norvegicus |
| 3 | In this report, we show that excess iodide coordinately suppresses the expression of the NIS and VEGF genes in FRTL-5 thyroid cells. | Iodides | solute carrier family 5 member 5 | Rattus norvegicus |
| 4 | We also demonstrate that the mechanism of iodide suppression of NIS gene expression is transcriptional, which is synergized by the addition of thyroglobulin. | Iodides | solute carrier family 5 member 5 | Rattus norvegicus |
| 5 | Based on the findings of reporter gene assays and electrophoretic gel mobility shift analysis, we also report two novel DNA binding proteins that responded specifically to iodide and modulated NIS promoter activity. | Iodides | solute carrier family 5 member 5 | Rattus norvegicus |