Title : 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors.

Pub. Date : 2010 Feb 15

PMID : 20123154






1 Functional Relationships(s)
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1 Making the phenylethylamine scaffold rigid by fixing the amine chain in an extended six-membered ring conformation increased MAO-B (but not MAO-A) inhibitory activity relative to the more flexible alpha-methylated derivative. Amines monoamine oxidase B Homo sapiens