Pub. Date : 2010 Oct 15
PMID : 20112340
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. | flavokawain B | BCL2-like 11 (apoptosis facilitator) | Mus musculus | ||
| 2 | FKB induces apoptosis with an associated increased expression of proapoptotic proteins: death receptor-5, Bim and Puma and a decreased expression of inhibitors of apoptosis protein: XIAP and survivin. | flavokawain B | BCL2-like 11 (apoptosis facilitator) | Mus musculus | ||
| 3 | Knockdown of Bim expression by short-hairpin RNAs attenuates the inhibitory effect on anchorage-dependent and -independent growth and caspase cleavages induced by FKB. | flavokawain B | BCL2-like 11 (apoptosis facilitator) | Mus musculus | ||
| 4 | Furthermore, FKB treatment of mice bearing DU145 xenograft tumors results in tumor growth inhibition and increases Bim expression in tumor tissues. | flavokawain B | BCL2-like 11 (apoptosis facilitator) | Mus musculus | ||