Title : Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin.

Pub. Date : 2010 May

PMID : 20110258






2 Functional Relationships(s)
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1 Mitoxantrone (MTX), a topoisomerase II inhibitor, induced relocalization of Sam68 from the nucleoplasm to nuclear granules, together with several other RBPs involved in alternative splicing, such as TIA-1, hnRNP A1 and the SR proteins SC35 and ASF/SF2. Mitoxantrone TIA1 cytotoxic granule associated RNA binding protein Homo sapiens
2 Mitoxantrone (MTX), a topoisomerase II inhibitor, induced relocalization of Sam68 from the nucleoplasm to nuclear granules, together with several other RBPs involved in alternative splicing, such as TIA-1, hnRNP A1 and the SR proteins SC35 and ASF/SF2. Mitoxantrone TIA1 cytotoxic granule associated RNA binding protein Homo sapiens