Pub. Date : 2010 May
PMID : 20109548
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study we tested whether phosphodiesterase 5 (PDE5) inhibitors, sildenafil and vardenafil, would afford protection against 3-nitropropionic acid (3NP), which produces striatal lesions that closely mimic some of the neuropathological features of Huntington"s Disease (HD). | Vardenafil Dihydrochloride | phosphodiesterase 5A, cGMP-specific | Mus musculus |
| 2 | Animals treated with PDE5 inhibitors (sildenafil or vardenafil) showed improved neurologic scores, reduced the loss of striatal DARPP-32 protein levels and lesion volumes, and decreased calpain activation produced by 3NP. | Vardenafil Dihydrochloride | phosphodiesterase 5A, cGMP-specific | Mus musculus |