Title : Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.

Pub. Date : 2010 Jan 27

PMID : 20107068






3 Functional Relationships(s)
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1 This effect was blocked by inhibitors of the VEGF receptor flk-1 and Src kinase, but not by inhibitors of phosphatidylinositol-3-kinase or protein kinase C. VEGF also increased Tyr-14 phosphorylation of caveolin-1, and this was blocked by the Src inhibitor PP2. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 This effect was blocked by inhibitors of the VEGF receptor flk-1 and Src kinase, but not by inhibitors of phosphatidylinositol-3-kinase or protein kinase C. VEGF also increased Tyr-14 phosphorylation of caveolin-1, and this was blocked by the Src inhibitor PP2. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
3 Pharmacological activation of Src kinase activity mimicked the effects of VEGF on P-glycoprotein activity and Tyr-14 phosphorylation of caveolin-1. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus