Title : Sulfotyrosines of the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promote tumorigenesis through autocrine activation.

Pub. Date : 2010 Apr

PMID : 20106924






2 Functional Relationships(s)
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1 A chemokine-binding assay demonstrated that the tyrosine sulfate moieties were critical for vGPCR association with GRO-alpha (an agonist) but not with IP-10 (an inverse agonist). tyrosine O-sulfate C-X-C motif chemokine ligand 1 Homo sapiens
2 Indeed, GRO-alpha increased vGPCR-mediated AKT phosphorylation and vGPCR tumorigenesis in a sulfotyrosine-dependent manner. tyrosine O-sulfate C-X-C motif chemokine ligand 1 Homo sapiens