Pub. Date : 2010 Feb 26
PMID : 20102700
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4. | Metformin | fatty acid binding protein 4 | Homo sapiens |
2 | Metformin promoted the expression of carnitine palmitoyltransferase I (CPT-1), while reduced the expression of fatty acid-binding protein 4 (FABP4) which was involved in PA-induced lipid accumulation. | Metformin | fatty acid binding protein 4 | Homo sapiens |
3 | Metformin promoted the expression of carnitine palmitoyltransferase I (CPT-1), while reduced the expression of fatty acid-binding protein 4 (FABP4) which was involved in PA-induced lipid accumulation. | Metformin | fatty acid binding protein 4 | Homo sapiens |
4 | Quantitative real-time PCR showed that metformin regulates FABP4 expression at the transcriptional level. | Metformin | fatty acid binding protein 4 | Homo sapiens |
5 | Metformin reduced FABP4 expression by promoting FOXO1 nuclear exclusion and subsequently inhibiting its activity. | Metformin | fatty acid binding protein 4 | Homo sapiens |
6 | CONCLUSIONS: Taken together, these results suggest that metformin reduces lipid accumulation in macrophages by repressing FOXO1-mediated FABP4 transcription. | Metformin | fatty acid binding protein 4 | Homo sapiens |