Title : Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4.

Pub. Date : 2010 Feb 26

PMID : 20102700






6 Functional Relationships(s)
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Protein Name
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1 Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4. Metformin fatty acid binding protein 4 Homo sapiens
2 Metformin promoted the expression of carnitine palmitoyltransferase I (CPT-1), while reduced the expression of fatty acid-binding protein 4 (FABP4) which was involved in PA-induced lipid accumulation. Metformin fatty acid binding protein 4 Homo sapiens
3 Metformin promoted the expression of carnitine palmitoyltransferase I (CPT-1), while reduced the expression of fatty acid-binding protein 4 (FABP4) which was involved in PA-induced lipid accumulation. Metformin fatty acid binding protein 4 Homo sapiens
4 Quantitative real-time PCR showed that metformin regulates FABP4 expression at the transcriptional level. Metformin fatty acid binding protein 4 Homo sapiens
5 Metformin reduced FABP4 expression by promoting FOXO1 nuclear exclusion and subsequently inhibiting its activity. Metformin fatty acid binding protein 4 Homo sapiens
6 CONCLUSIONS: Taken together, these results suggest that metformin reduces lipid accumulation in macrophages by repressing FOXO1-mediated FABP4 transcription. Metformin fatty acid binding protein 4 Homo sapiens