Title : Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.

Pub. Date : 2010 Feb 26

PMID : 20097174






1 Functional Relationships(s)
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1 We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice. Carbamyl Phosphate carbamoyl-phosphate synthetase 1 Mus musculus