Title : The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina.

Pub. Date : 2009 Dec

PMID : 20092573






2 Functional Relationships(s)
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1 We examined the role of GlyT1, the high-affinity glycine transporter, in the mouse retina with an emphasis on the role of glycine as a coagonist of N-methyl-D-aspartic acid (NMDA) receptors. Glycine solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Mus musculus
2 Capillary electrophoresis was used to separate and quantitatively measure glycine release from isolated retina preparations; pharmacologically blocking GlyT1 with N-[3-([1,1-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine in the WT retina generated a significantly larger accumulation of glycine into the bathing environment when compared with the GlyT1(-/+) retinas. Glycine solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Mus musculus