Pub. Date : 2010 Jun
PMID : 20091774
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. | Serine | serine racemase | Homo sapiens |
| 2 | It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. | Serine | serine racemase | Homo sapiens |
| 3 | Candidate mechanisms include SRR operating in alpha,beta-eliminase mode (converting D-serine to pyruvate) and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is implicated. | Serine | serine racemase | Homo sapiens |
| 4 | Incubation with serine enantiomers decreased [(3)H]D-serine uptake and ASCT2 mRNA and increased SRR immunoreactivity but did not alter DAO immunoreactivity, and DAO activity remained undetectable. | Serine | serine racemase | Homo sapiens |
| 5 | SRR overexpression increased D-serine and pyruvate and decreased [(3)H]D-serine uptake and ASCT2 mRNA but did not affect DAO. | Serine | serine racemase | Homo sapiens |