Title : Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae.

Pub. Date : 2010 May 1

PMID : 20091767






1 Functional Relationships(s)
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1 Over-expression of the catalytic domain of HMG1, both from the genome and plasmid, resulted in higher production of cubebol, a plant originating sesquiterpene, and increased squalene accumulation. Squalene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Saccharomyces cerevisiae S288C