Title : Discovery of novel poly(ADP-ribose) glycohydrolase inhibitors by a quantitative assay system using dot-blot with anti-poly(ADP-ribose).

Pub. Date : 2010 Feb 19

PMID : 20079708






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PARG hydrolyzes glycosidic linkages of poly(ADP-ribose) synthesized by PARP and liberates ADP-ribose residues. Ribose poly(ADP-ribose) glycohydrolase Homo sapiens
2 However, previous PARG assay systems are not appropriate for high-throughput screening because PARG activity is measured by radioactivities of ADP-ribose residues released from radioisotope (RI)-labeled poly(ADP-ribose). Ribose poly(ADP-ribose) glycohydrolase Homo sapiens