Pub. Date : 2010 Apr
PMID : 20075041
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Haemophilus influenzae ORF designated HI1275 in the Rd KW20 genomic sequence encodes a putative S-adenosyl methyltransferase with significant similarity to tellurite-resistance determinants (tehB) in other species. | tellurous acid | SAM-dependent methyltransferase TehB | Haemophilus influenzae Rd KW20 |
| 2 | Deletion of tehB leads to an increase in sensitivity both to tellurite and to the oxidizing agents cumene hydroperoxide, tert-butyl hydroperoxide and hydrogen peroxide. | tellurous acid | SAM-dependent methyltransferase TehB | Haemophilus influenzae Rd KW20 |
| 3 | Examination of the regulation kinetics indicated that transcription of tehB was independent of both tellurite exposure and oxidative stress. | tellurous acid | SAM-dependent methyltransferase TehB | Haemophilus influenzae Rd KW20 |
| 4 | These data demonstrate that H. influenzae tehB plays a role in both resistance to oxidative damage and haem uptake/utilization, protects H. influenzae from tellurite exposure, and is important for virulence of this organism in an animal model of invasive disease. | tellurous acid | SAM-dependent methyltransferase TehB | Haemophilus influenzae Rd KW20 |