Pub. Date : 2010 Feb 26
PMID : 20074615
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine stimulates transcriptional activity of the human dopamine transporter gene. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |
| 2 | Nicotine modulates dopaminergic activity in the central nervous system by acting on the reuptake system, including the dopamine transporter (DAT), although precisely remains unclear. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |
| 3 | Nicotine modulates dopaminergic activity in the central nervous system by acting on the reuptake system, including the dopamine transporter (DAT), although precisely remains unclear. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |
| 4 | Here we investigated the effect of nicotine on the transcriptional regulation of the human DAT (hDAT) gene by conducting luciferase reporter assays. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |
| 5 | Here we investigated the effect of nicotine on the transcriptional regulation of the human DAT (hDAT) gene by conducting luciferase reporter assays. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |
| 6 | Nicotine enhanced the transcription of hDAT gene constructs in transiently transfected SK-N-SH cells. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |
| 7 | Deletion of intron 1, known as a silencer element of the hDAT gene, abolished nicotine"s stimulatory effect. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |
| 8 | These results suggest a nicotinic cholinergic mechanism to be involved in the nicotine-induced up-regulation of DAT gene expression. | Nicotine | solute carrier family 6 member 3 | Homo sapiens |