Title : Cellular and molecular mechanisms of bromate-induced cytotoxicity in human and rat kidney cells.

Pub. Date : 2010 Feb 28

PMID : 20067818






1 Functional Relationships(s)
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1 The antioxidant ascorbic acid inhibited BrO(3)(-)-induced p38 activation, G2/M arrest, p-p53, p21 and cyclin B1 expression; however, ascorbic acid had no effect on BrO(3)(-)-induced formation of 8-OHdG, a marker of DNA oxidative damage, whose increases preceded cell death by 24h. Ascorbic Acid tumor protein p53 Homo sapiens