Title : Novel synthetic LPDs consisting of different cholesterol derivatives for gene transfer into hepatocytes.

Pub. Date : 2010 Aug

PMID : 20067439






2 Functional Relationships(s)
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1 In agreement with the "clustering effect" known to occur with more complex oligomeric structures, the addition of galactose residues under optimized spatial arrangement condition invariably increased the transfect efficiency into hepatoma cells, which can be owed to the sufficient binding of galactose ligands to the ASGPR on hepatocytes. Galactose asialoglycoprotein receptor 1 Homo sapiens
2 In agreement with the "clustering effect" known to occur with more complex oligomeric structures, the addition of galactose residues under optimized spatial arrangement condition invariably increased the transfect efficiency into hepatoma cells, which can be owed to the sufficient binding of galactose ligands to the ASGPR on hepatocytes. Galactose asialoglycoprotein receptor 1 Homo sapiens