Pub. Date : 2010 Apr
PMID : 20064835
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In order to identify their molecular targets in such cells, we have analyzed gene expression profile of primary human macrophages treated by the prototypical PAH benzo(a)pyrene (BaP), using pangenomic oligonucleotides microarrays. | Polycyclic Aromatic Hydrocarbons | prohibitin 2 | Homo sapiens |
| 2 | Their bioinformatic analysis indicated that biological functions linked to immunity, inflammation, and cell death were among the most affected by BaP in human macrophages and that the AhR and p53 signaling pathways were the most significant canonical pathways activated by the PAH. | Polycyclic Aromatic Hydrocarbons | prohibitin 2 | Homo sapiens |
| 3 | AhR and p53 implications were moreover fully confirmed by the prevention of BaP-related upregulation of some selected target genes by AhR silencing or the use of pifithrin-alpha, an inhibitor of PAH bioactivation-related DNA damage/p53 pathways. | Polycyclic Aromatic Hydrocarbons | prohibitin 2 | Homo sapiens |