Title : Synergistic activity of letrozole and sorafenib on breast cancer cells.

Pub. Date : 2010 Nov

PMID : 20054642






1 Functional Relationships(s)
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1 Sorafenib inhibited cell proliferation in a concentration-dependent manner; this effect was not dependent on sorafenib-mediated inhibition of Raf1, but involved the down-regulation of mTORC1 and its targets p70S6K and 4E-binding protein 1 (4E-BP1). Sorafenib CREB regulated transcription coactivator 1 Mus musculus