Title : Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells.

Pub. Date : 2010 Jun 1

PMID : 20051385






3 Functional Relationships(s)
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1 CSE KO mice showed much lower level of phosphorylated extracellular signal-regulated kinase (ERK1/2) in mesentery arteries compared with those of WT mice, and exogenous H2S induced more phosphorylation of ERK1/2 in SMCs-KO compared with that in SMCs-WT. Hydrogen Sulfide mitogen-activated protein kinase 3 Mus musculus
2 CSE KO mice showed much lower level of phosphorylated extracellular signal-regulated kinase (ERK1/2) in mesentery arteries compared with those of WT mice, and exogenous H2S induced more phosphorylation of ERK1/2 in SMCs-KO compared with that in SMCs-WT. Hydrogen Sulfide mitogen-activated protein kinase 3 Mus musculus
3 These cellular effects of H2S are mediated by phosphorylation of ERK1/2 and altered expression of cyclin D1 and p21(Cip/WAF-1). Hydrogen Sulfide mitogen-activated protein kinase 3 Mus musculus