Title : Molecular mechanisms of melatonin anticancer effects.

Pub. Date : 2009 Dec

PMID : 20050373






1 Functional Relationships(s)
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1 Melatonin"s blockade of BMAL1 expression is associated with the decreased expression of SIRT1, a member of the Silencing Information Regulator family and a histone and protein deacetylase that inhibits the expression of DNA repair enzymes (p53, BRCA1 & 2, and Ku70) and the expression of apoptosis-associated genes. Melatonin tumor protein p53 Homo sapiens