Title : Estradiol supplementation helps overcome central leptin resistance of ovariectomized mice on a high fat diet.

Pub. Date : 2010 Mar

PMID : 20049675






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1 Finally, leptin or saline was injected into the third ventricle, and food intake and body weight were measured for 36 h. In ovariectomized mice fed a standard diet, the decrease in food intake and body weight was significant and was pronounced in 17beta-estradiol-3-benzoate-supplemented mice. estradiol 3-benzoate leptin Mus musculus
2 We showed for the first time that central insensitivity to leptin in ovariectomized diet-induced obese mice was restored with 17beta-estradiol-3-benzoate supplementation, which also attenuated most of the parameters of metabolic syndrome. estradiol 3-benzoate leptin Mus musculus