Pub. Date : 2010 Jan 1
PMID : 20049322
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Indeed, Provinols, delphinidin and ERalpha agonists, 17-beta-estradiol and PPT, are able to induce endothelial vasodilatation in aorta from ERalpha Wild-Type but not from Knock-Out mice, by activation of nitric oxide (NO) pathway in endothelial cells. | delphinidin | estrogen receptor 1 (alpha) | Mus musculus |
2 | Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production. | delphinidin | estrogen receptor 1 (alpha) | Mus musculus |
3 | Furthermore, direct interaction between delphinidin and ERalpha activator site is demonstrated using both binding assay and docking. | delphinidin | estrogen receptor 1 (alpha) | Mus musculus |
4 | CONCLUSIONS/SIGNIFICANCE: This study provides evidence that red wine polyphenols, especially delphinidin, exert their endothelial benefits via ERalpha activation. | delphinidin | estrogen receptor 1 (alpha) | Mus musculus |