Title : Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium.

Pub. Date : 2010 Jan 1

PMID : 20049322






4 Functional Relationships(s)
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1 Indeed, Provinols, delphinidin and ERalpha agonists, 17-beta-estradiol and PPT, are able to induce endothelial vasodilatation in aorta from ERalpha Wild-Type but not from Knock-Out mice, by activation of nitric oxide (NO) pathway in endothelial cells. delphinidin estrogen receptor 1 (alpha) Mus musculus
2 Besides, silencing the effects of ERalpha completely prevented the effects of Provinols and delphinidin to activate NO pathway (Src, ERK 1/2, eNOS, caveolin-1) leading to NO production. delphinidin estrogen receptor 1 (alpha) Mus musculus
3 Furthermore, direct interaction between delphinidin and ERalpha activator site is demonstrated using both binding assay and docking. delphinidin estrogen receptor 1 (alpha) Mus musculus
4 CONCLUSIONS/SIGNIFICANCE: This study provides evidence that red wine polyphenols, especially delphinidin, exert their endothelial benefits via ERalpha activation. delphinidin estrogen receptor 1 (alpha) Mus musculus