Pub. Date : 2010 Mar
PMID : 20048018
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine. | Serotonin | FEV transcription factor, ETS family member | Homo sapiens |
| 2 | Compared with those in the matched normal human SI, FEV expression levels were significantly elevated in primary NETs (20-fold, P<0.0001), lymph node metastases (35-fold, P=0.004), and NET liver metastases (22-fold, P<0.0001) resected from patients with serotonin excess. | Serotonin | FEV transcription factor, ETS family member | Homo sapiens |
| 3 | Using recombination-based cell lineage tracing, we found that FEV-positive cells give rise to serotonin-producing cells in the SI. | Serotonin | FEV transcription factor, ETS family member | Homo sapiens |
| 4 | We conclude that FEV expression identifies serotonin-producing cells in normal and neoplastic SI and is a novel target for diagnosis of patients with NETs of the SI. | Serotonin | FEV transcription factor, ETS family member | Homo sapiens |