Title : Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.

Pub. Date : 2010 Feb 26

PMID : 20044479






1 Functional Relationships(s)
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1 Exposure of MCF-7 breast cancer cells to IGF-1 rapidly and transiently induced tyrosine phosphorylation and activation of phosphoinositide-dependent kinase-1 (PDK1). Tyrosine insulin like growth factor 1 Homo sapiens