Title : Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix.

Pub. Date : 2010 Jan 27

PMID : 20041650






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We report a stabilized alpha-helix designed to target the binding interface between the C-terminal transactivation domain (C-TAD) of hypoxia-inducible factor 1alpha (HIF-1alpha) and cysteine-histidine rich region (CH1) of transcriptional coactivator CBP/p300. Histidine CREB binding protein Homo sapiens