Title : Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate.

Pub. Date : 2010 Mar

PMID : 20032236






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 An increase in PIP(2) by topical lingual application of U73122 (a phospholipase C blocker) or diC8-PIP(2) (a short chain synthetic PIP(2)) inhibited the control NaCl + Bz CT response and decreased its sensitivity to RTX. resiniferatoxin prolactin induced protein Mus musculus
2 A decrease in PIP(2) by topical lingual application of phenylarsine oxide (a phosphoinositide 4 kinase blocker) enhanced the control NaCl + Bz CT response, increased its sensitivity to RTX stimulation, and inhibited the desensitization of the CT response at RTX concentrations >1 x 10(-6) M. The ENaC-dependent NaCl CT responses were not altered by changes in PIP(2). resiniferatoxin prolactin induced protein Mus musculus
3 A decrease in PIP(2) by topical lingual application of phenylarsine oxide (a phosphoinositide 4 kinase blocker) enhanced the control NaCl + Bz CT response, increased its sensitivity to RTX stimulation, and inhibited the desensitization of the CT response at RTX concentrations >1 x 10(-6) M. The ENaC-dependent NaCl CT responses were not altered by changes in PIP(2). resiniferatoxin prolactin induced protein Mus musculus