Title : Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate.

Pub. Date : 2010 Mar

PMID : 20032236






2 Functional Relationships(s)
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1 A decrease in PIP(2) by topical lingual application of phenylarsine oxide (a phosphoinositide 4 kinase blocker) enhanced the control NaCl + Bz CT response, increased its sensitivity to RTX stimulation, and inhibited the desensitization of the CT response at RTX concentrations >1 x 10(-6) M. The ENaC-dependent NaCl CT responses were not altered by changes in PIP(2). oxophenylarsine prolactin induced protein Mus musculus
2 A decrease in PIP(2) by topical lingual application of phenylarsine oxide (a phosphoinositide 4 kinase blocker) enhanced the control NaCl + Bz CT response, increased its sensitivity to RTX stimulation, and inhibited the desensitization of the CT response at RTX concentrations >1 x 10(-6) M. The ENaC-dependent NaCl CT responses were not altered by changes in PIP(2). oxophenylarsine prolactin induced protein Mus musculus