Pub. Date : 2009 Dec
PMID : 20029546
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat. | Nitrites | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 2 | It has been hypothesized that deoxyhemoglobin, xanthine oxidoreductase, mitochondrial aldehyde dehydrogenase, and other heme proteins can reduce nitrite to NO, but studies in the literature have not identified the mechanism in the intact rat, and several studies report no effect of inhibitors of xanthine oxidoreductase. | Nitrites | aldehyde dehydrogenase 2 family member | Rattus norvegicus |
| 3 | The results of these studies suggest that nitrite can be reduced to vasoactive NO in the systemic vascular bed of the rat by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase and that the 2 pathways of nitrite activation act in a parallel manner. | Nitrites | aldehyde dehydrogenase 2 family member | Rattus norvegicus |