Pub. Date : 2010 Mar
PMID : 20028736
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | First, we determined that PCNA monoubiquitination by RAD18 is necessary for efficient bypass of cisplatin adducts by the TLS polymerases eta (Poleta), REV1, and zeta (Polzeta) based on the observations that depletion of these proteins individually leads to decreased cell survival, cell cycle arrest in S phase, and activation of the DNA damage response. | Cisplatin | RAD18 E3 ubiquitin protein ligase | Homo sapiens |
| 2 | Together, our findings indicate that REV1 and Polzeta facilitate repair of interstrand cross-links independently of PCNA monoubiquitination and Poleta, whereas RAD18 plus Poleta, REV1, and Polzeta are all necessary for replicative bypass of cisplatin intrastrand DNA cross-links. | Cisplatin | RAD18 E3 ubiquitin protein ligase | Homo sapiens |