Pub. Date : 2010 Feb 26
PMID : 20026605
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain. | Polysaccharides | CD207 molecule | Homo sapiens |
| 2 | Here, we investigated the glycan-binding specificity of Langerin using comprehensive glycoconjugate microarray, quantitative frontal affinity chromatography, and conventional cell biological analyses. | Polysaccharides | CD207 molecule | Homo sapiens |
| 3 | Langerin also recognized pathogenic fungi, such as Candida and Malassezia, expressing heavily mannosylated glycans. | Polysaccharides | CD207 molecule | Homo sapiens |
| 4 | These observations provide strong evidence that Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain. | Polysaccharides | CD207 molecule | Homo sapiens |