Pub. Date : 2010 May 1
PMID : 20026082
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 2 | The aim of this study was to evaluate the effect of the thiazolidinedione rosiglitazone (BRL 49653) on GLUT4 in adipocytes. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 3 | When applied during differentiation, rosiglitazone dose dependently augmented GLUT4 expression along with the formation of lipid droplets. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 4 | Treatment of fully differentiated adipocytes with rosiglitazone also led to increases in GLUT4 at the plasma membrane. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 5 | The augmentation in cell surface GLUT4 levels was maintained in adipocytes that were rendered insulin-resistant in vitro by a 24h insulin treatment and moreover in these cells rosiglitazone also fully restored insulin-induced GLUT4 translocation. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 6 | The augmentation in cell surface GLUT4 levels was maintained in adipocytes that were rendered insulin-resistant in vitro by a 24h insulin treatment and moreover in these cells rosiglitazone also fully restored insulin-induced GLUT4 translocation. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 7 | We conclude that in adipocytes, rosiglitazone increases cell surface GLUT4 levels by increasing its endosomal recycling and restores insulin-induced GLUT4 translocation in insulin resistance. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 8 | We conclude that in adipocytes, rosiglitazone increases cell surface GLUT4 levels by increasing its endosomal recycling and restores insulin-induced GLUT4 translocation in insulin resistance. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |
| 9 | These results implicate novel modes of action on GLUT4 that are all likely to contribute to the insulin-sensitizing effect of rosiglitazone in type 2 diabetes. | Rosiglitazone | solute carrier family 2 member 4 | Homo sapiens |