Pub. Date : 2010 Mar 18
PMID : 20023700
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. | Cyclosporine | peptidylprolyl isomerase D | Homo sapiens |
| 2 | Under knockdown conditions, the inhibitory effects of TPR ligands, cyclosporine A (CsA) and FK506, on AR activity were not observed, indicating that Cyp40 and FKBP51 are the targets of CsA and FK506, respectively. | Cyclosporine | peptidylprolyl isomerase D | Homo sapiens |
| 3 | Our findings show that FKBP51 and Cyp40 are positive regulators of AR that can be selectively targeted by CsA and FK506 to achieve inhibition of androgen-induced cell proliferation. | Cyclosporine | peptidylprolyl isomerase D | Homo sapiens |