Title : Dissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt.

Pub. Date : 2010 Feb 19

PMID : 20022950






1 Functional Relationships(s)
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1 We conclude that in chronic insulin- and dexamethasone-treated cells, acute activation with insulin itself is required to activate a feedforward inhibitory pathway likely emanating from phosphatidylinositol 3-kinase that converges on a target downstream of Akt to cause insulin resistance. Dexamethasone AKT serine/threonine kinase 1 Homo sapiens