Title : Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition.

Pub. Date : 2009 Dec

PMID : 20009910






2 Functional Relationships(s)
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1 RESULTS: We found that treatment with MS-275, compared to vorinostat (SAHA), valproic acid or trichostatin A, was most effective in E-cadherin up-regulation and persistence in non-small cell lung cancers. entinostat cadherin 1 Homo sapiens
2 Importantly, blocking E-cadherin induction by short hairpin RNA resulted in less inhibition by MS-275, implicating the epithelial to mesenchymal phenotype process as a contributing factor. entinostat cadherin 1 Homo sapiens