Title : Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites.

Pub. Date : 2010 Mar

PMID : 20007295






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Coincubation with TAM, a high-affinity UGT1A4 substrate, resulted in a concentration-dependent activation/inhibition effect on DHT and t-AND glucuronidation, whereas LTG, a low-affinity UGT1A4 substrate, noncompetitively inhibited both processes. Tamoxifen UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 Coincubation with TAM, a high-affinity UGT1A4 substrate, resulted in a concentration-dependent activation/inhibition effect on DHT and t-AND glucuronidation, whereas LTG, a low-affinity UGT1A4 substrate, noncompetitively inhibited both processes. Tamoxifen UDP glucuronosyltransferase family 1 member A4 Homo sapiens
3 TAM displayed substrate inhibition kinetics, suggesting that TAM may have two binding sites in UGT1A4. Tamoxifen UDP glucuronosyltransferase family 1 member A4 Homo sapiens
4 TAM displayed substrate inhibition kinetics, suggesting that TAM may have two binding sites in UGT1A4. Tamoxifen UDP glucuronosyltransferase family 1 member A4 Homo sapiens