Title : Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Pub. Date : 2010 Jan 15

PMID : 20005727






3 Functional Relationships(s)
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1 The purpose of the present study was to evaluate new oxime compounds to reactivate acetylcholinesterase (AChE) inhibited by the OP paraoxon. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The purpose of the present study was to evaluate new oxime compounds to reactivate acetylcholinesterase (AChE) inhibited by the OP paraoxon. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Interestingly, oximes with a heterocyclic linker inhibited AChE at higher concentration (10(-3)M), whereas their ability to reactivate was increased at lower concentrations (10(-4)M and 10(-5)M). Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens