Title : The role of HMGCR alternative splicing in statin efficacy.

Pub. Date : 2009 Jul

PMID : 20005478






1 Functional Relationships(s)
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1 Using a panel of immortalized lymphocyte cell lines incubated with simvastatin, we recently found that the magnitude of expression of an alternatively spliced HMGCR transcript lacking exon 13 was inversely correlated with in vivo reductions of total cholesterol, low-density lipoprotein cholesterol, apoB, and triglycerides after statin treatment of the individuals from whom the cells were derived. Triglycerides 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens