Pub. Date : 2010 Sep 6
PMID : 20005217
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. | Polyethylene Glycols | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. | Polyethylene Glycols | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | By profiling the pharmacokinetic behavior of an array of well-defined hypolysine human mutant AChE molecules following PEGylation, we now determine that the duration of these enzyme forms in the circulation of rhesus macaques correlates with their number of appended PEG moieties, and is influenced by the actual location of the PEG chains at the molecule surface, as well. | Polyethylene Glycols | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | By profiling the pharmacokinetic behavior of an array of well-defined hypolysine human mutant AChE molecules following PEGylation, we now determine that the duration of these enzyme forms in the circulation of rhesus macaques correlates with their number of appended PEG moieties, and is influenced by the actual location of the PEG chains at the molecule surface, as well. | Polyethylene Glycols | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Thus, an inverse relationship between anti-AChE antibody production and PEG loading was observed following repeated administration of the different PEGylated hypolysine human AChEs to mice. | Polyethylene Glycols | acetylcholinesterase (Cartwright blood group) | Homo sapiens |