Pub. Date : 2009 Dec 14
PMID : 20003459
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2. | Deoxyglucose | X-box binding protein 1 | Homo sapiens |
| 2 | Moreover, XBP-1, which is known to be transcriptionally regulated by ATF6 and functionally activated by IRE1 alpha, was found to play an important role in 2-DG-mediated transcriptional up-regulation of TRAIL-R2 in melanoma cells. | Deoxyglucose | X-box binding protein 1 | Homo sapiens |
| 3 | CONCLUSION: These results indicate that 2-DG sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-2 via the ATF6/IRE1 alpha/XBP-1 axis of the unfolded protein response. | Deoxyglucose | X-box binding protein 1 | Homo sapiens |