Pub. Date : 2010 Feb 24
PMID : 20001965
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 2 | In the present paper, we report that cellular polyamines regulate MEK-1 expression at the post-transcriptional level through the RNA-binding protein HuR (Hu-antigen R) in IECs (intestinal epithelial cells). | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 3 | In the present paper, we report that cellular polyamines regulate MEK-1 expression at the post-transcriptional level through the RNA-binding protein HuR (Hu-antigen R) in IECs (intestinal epithelial cells). | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 4 | HuR silencing rendered the MEK-1 mRNA unstable and inhibited its translation, thus preventing increases in MEK-1 mRNA and protein in polyamine-deficient cells. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 5 | Inhibition of MEK-1 expression by MEK-1 silencing or HuR silencing prevented the increased resistance of polyamine-deficient cells to apoptosis. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 6 | These results indicate that polyamines destabilize the MEK-1 mRNA and repress its translation by inhibiting the association between HuR and the MEK-1 transcript. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |