Pub. Date : 2010 Jan
PMID : 20001559
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The impairment of cAMP and/or cGMP generation by overexpression of PDE isoforms that has been described in various cancer pathologies, and the effects of PDE inhibitors in tumour models in vitro and in vivo, may offer promising insight into future cancer treatments because of the numerous advantages of PDE inhibitors. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 2 | WHAT THE READER WILL GAIN: PDEs have been studied in a variety of tumours; data have suggested that the levels of PDE activity are elevated and, therefore, the ratio of cGMP to cAMP is affected. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 3 | TAKE HOME MESSAGE: Impaired cAMP and/or cGMP generation upon overexpression of PDE isoforms has been described in various cancer pathologies. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 4 | Inhibition of selective PDE isoforms, which raises the levels of intracellular cAMP and/or cGMP, induces apoptosis and cell cycle arrest in a broad spectrum of tumour cells and regulates the tumour microenvironment. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |