Title : Low-dose fludarabine increases rituximab cytotoxicity in B-CLL cells by triggering caspases activation in vitro.

Pub. Date : 2010 Jan

PMID : 20001234






2 Functional Relationships(s)
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1 Consistent with the viability assay, we found an increased caspase-3 activity together with activation of caspase-9 in B-CLL cells sensitive to sequential non-cytotoxic fludarabine and rituximab exposure. fludarabine caspase 3 Homo sapiens
2 Non-cytotoxic fludarabine concentrations may sensitize B-CLL cells to rituximab-mediated cytotoxicity via caspase-3 activation. fludarabine caspase 3 Homo sapiens