Title : Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.

Pub. Date : 2010 Feb

PMID : 19962379






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We now confirm that exposure to oxidants induces lipoxidative modification of Na(V)1.5 and that the selective isoketal scavengers block voltage-dependent changes in sodium current by the oxidant tert-butylhydroperoxide, both in cells heterologously expressing Na(V)1.5 and in a mouse cardiac myocyte cell line (HL-1). tert-Butylhydroperoxide sodium channel, voltage-gated, type V, alpha Mus musculus
2 We now confirm that exposure to oxidants induces lipoxidative modification of Na(V)1.5 and that the selective isoketal scavengers block voltage-dependent changes in sodium current by the oxidant tert-butylhydroperoxide, both in cells heterologously expressing Na(V)1.5 and in a mouse cardiac myocyte cell line (HL-1). tert-Butylhydroperoxide sodium channel, voltage-gated, type V, alpha Mus musculus