Title : Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.

Pub. Date : 2010 Mar

PMID : 19959964






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cerulein (Cae), a CCK-1R agonist, and pentagastrin, a CCK-2R agonist, dose-dependently increased SS release, 3-fold at 1 mumol/L Cae, 2.5-fold at 10 mumol/L pentagastrin, with occupation of both CCKRs confirmed by L-364,178 and L-365,260 inhibition of CCK receptors 1 and 2. Pentagastrin cholecystokinin B receptor Rattus norvegicus