Title : Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process.

Pub. Date : 2010 Apr

PMID : 19957203






1 Functional Relationships(s)
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1 Tyrphostin AG126 significantly attenuated the 7-ketocholesterol-induced decrease in cytosolic Bid and Bcl-2 levels, increase in cytosolic pro-apoptotic Bax levels, mitochondrial membrane potential loss, cytochrome c release and subsequent caspase-3 activation. 7-ketocholesterol BH3 interacting domain death agonist Rattus norvegicus